When baking ziti in the oven, it is important to cover your casserole dish loosely with foil, so that it doesn’t stick to the cheese and set your oven to 350 degrees Fahrenheit. The bake time for ziti is 20 to 25 minutes, covered with aluminum foil. Once the timer goes off, remove the foil and switch the oven setting from bake to broil. Back the ziti uncovered for an additional 5 to 10 minutes. The extra few minutes under the broiler can help to brown the cheese and further bake it, but keep a close eye on your ziti while it broils because oven broilers can vary and you want your cheese to be lightly browned on top.